This kind of 3D physics simulation for audio has been done academically in the past, with projects like GENESIS, mi-gen, Tao, and others, but it has always been very experimental and not a commercially available product. Most of the past simulations have been offline (non-realtime) as well, and/or have not had a user-friendly GUI.
Anukari takes the idea of a 3D physics simulation for sound design, and makes it usable fully in real-time by utilizing the user’s graphics card (GPU) for physics computation, and also adds a simple user-friendly interface so that anybody can construct a 3D physics instrument from scratch.
Anukari also is innovative by visualizing the 3D physics simulation completely in real time, with customizable 3D graphics. This could be used to project the visuals during a live performance, or to stream online.
An Anukari instrument can easily have 1,000s of parameters, since the user can create hundreds of physics objects and each one has several parameters that could be modulated. So it is an ideal synthesizer to use with MPE, because the possibilities for expressive control are near-limitless.
As far as I’m aware, there is no other commercially-available synthesizer out there that’s really anything like Anukari.