Looking on the internet, I see that there is at least 1 upset customer regarding this keyboard/controller - evidently with W10. Suggested that there is a problem regarding W10 turning USB link off if not used for a while, and no easy way to turn it back on again.
The problem seems to be with W10 specifically. As far as W10 is concerned, this may be a legitimate power saving 'feature', but it causes problems with this device.
Don't know if a new driver might be released. There is a later (?) driver that specifically mentions W10.
As stated, you need to check with M-Audio, or one of the larger re-sellers.